CRΘM Director, Rochelle Tractenberg, has 20 years of experience in clinical trials design, analysis, and particularly, outcomes/endpoint development, evaluation and validation in the neurological and neuropsychological domains. A Fellow of the American Statistical Association, she has consulted nationally and internationally, in academia, government, and industry; has taught biostatistics at the FDA; and has been nominated three times (2010, 2011, 2014) for the American Statistical Association’s Excellence in Consulting award. Dr. Rich Jones is a co-editor of a recently published book, Newsom, J.T., Jones, R.N., & Hofer, S.M. (eds.) (2011). Longitudinal Data Analysis A Practical Guide for Researchers in Aging, Health, and Social Sciences. New York: Routledge. This work details many critical dimensions that must be integrated when measurement is featured in research. Dr. Rob Pietrzak published with Dr. Tractenberg a simulation-based evaluation of the potential (represented by effect size estimate distributions) based on a diverse collection of definitions for the otherwise-seemingly-unified construct of intra-individual variability in 2011. Dr. Frances Yang is a gerontologist and epidemiologist with training in advanced quantitative methods using latent variable modeling from Harvard Medical School, Beth Israel Deaconess Medical Center, and the Institute for Aging Research at Hebrew SeniorLife. Currently, she is an Assistant Professor of Epidemiology at Georgia Regents University and the Course Director of Evidence-Based Medicine at the Medical College of Georgia, and recently (2014) published an article outlining the role of modern measurement (item response) theory in determining measurement validity. Dr. Toshi Yumoto has been a psychometrician for 17 years and has been modeling the measurement features of clinical outcomes in psychology, psychiatry, and cognitive neuropsychology for 15 years, working with Dr. Tractenberg on specifically neurological outcomes since 2006.